SB 203580 (hydrochloride)
- Product Name
- SB 203580 (hydrochloride)
- CAS No.
- 869185-85-3
- Chemical Name
- SB 203580 (hydrochloride)
- Synonyms
- RWJ 64809 hydrochloride;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
- CBNumber
- CB52592405
- Molecular Formula
- C21H17ClFN3OS
- Formula Weight
- 413.9
- MOL File
- 869185-85-3.mol
SB 203580 (hydrochloride) Property
- storage temp.
- -20C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
- form
- Bright yellow solid
- Water Solubility
- Soluble to 25 mM in water
- Stability:
- Hygroscopic
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 559395
- Product name
- SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem<br />SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells).
- Packaging
- 1mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 559395
- Product name
- SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem<br />SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells).
- Packaging
- 10mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- 13344
- Product name
- SB 203580 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 13344
- Product name
- SB 203580 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 13344
- Product name
- SB 203580 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $493
- Updated
- 2024/03/01
SB 203580 (hydrochloride) Chemical Properties,Usage,Production
Uses
SB 203580 Hydrochloride is a protein kinase inhibitor.
General Description
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
Biological Activity
sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2].
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
References
[1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96.